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“Off” time in
Parkinson’s
disease
(PD) can keep
you
from moving the

way you want to.

You can have “off” time when your PD medications start to wear off.

Actor Portrayal

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“Off” time is when Parkinson’s symptoms return
between medication doses

Within 5 years of starting levodopa/carbidopa, half of people living with PD begin to
experience “off” time, including problems with MOVEMENT.

As PD progresses, you may have more “off” time

There are many signs of “off” time, including:

  • Tremors
  • Difficulty
    walking
  • Slowness
  • Stiffness
  • Partial or total
    inability to move

If you’re experiencing signs of “off” time, your doctor may add an additional medication, like NOURIANZ, to help.

Think you’re having “off” time? Track your symptoms with the Doctor Discussion Guide and talk to your doctor about whether adding NOURIANZ can help.

Download the Doctor Discussion Guide

Adenosine and dopamine are naturally occurring
chemicals in the brain that help control movement

Typically, both adenosine and dopamine work together in balance to help you
move the way you want to move. But in PD, that’s not the case.

There’s more to think about than just dopamine.