There is more to Parkinson's disease (PD) than dopamine...there is also adenosine

Research suggests that adenosine A2A receptors play an important role in PD:

  • Dopamine signals the body to move and adenosine works to slow the body down
  • In PD, A2A receptors become overactive, which can cause problems with movement
Dopamine works like pushing down on the gas pedal of a car, resulting in movement. Adenosine works like applying the brake, slowing movement. How dopamine and adenosine work in Parkinson's disease

NOURIANZ is the first and only medicine for PD that targets the adenosine A2A receptor

  • Until now, there have been no medications for PD that target adenosine A2A receptors
  • NOURIANZ is nondopaminergic
  • NOURIANZ is unique and works specifically on adenosine A2A receptors, unlike other medications for PD
  • The exact way that NOURIANZ works to treat PD is unknown
NOURIANZ is the first and only medicine for Parkinson’s disease that blocks the adenosine A2A receptor.

Since 2013, NOURIANZ has been prescribed to more than 50,000 people in Japan.

Since 2013, NOURIANZ has been prescribed to more than 50,000 people in Japan.

Taking NOURIANZ with other medications

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

  • Have a history of abnormal movement (dyskinesia)
  • Have reduced liver function
  • Smoke cigarettes
  • Are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Talk to your doctor if you have any questions about your medications. Talk to your doctor if you have any questions about your medications.

NOURIANZ is a tablet taken one time each day.

  • Take NOURIANZ exactly as your healthcare provider tells you to
  • If you take too much NOURIANZ, call your healthcare provider or go to the nearest hospital emergency room right away
  • You can take NOURIANZ at any time of the day or night—work with your healthcare provider to decide what's best for you

How should I store NOURIANZ?

  • Store NOURIANZ at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep NOURIANZ and all medicines out of the reach of children
 

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of abnormal movement (dyskinesia)
  • have a history of psychotic thinking or behavior
  • have reduced liver function
  • smoke cigarettes or use other tobacco products
  • are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

  • uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
  • hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
    • being overly suspicious or feeling people want to harm you (paranoid ideation)
    • believing things that are not real (delusions)
    • seeing or hearing things that are not real (hallucinations)
    • confusion
    • increased activity or talking (mania)
    • disorientation
    • aggressive behavior
    • agitation
    • delirium (decreased awareness of things around you)
  • unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Patient Information for NOURIANZ.

Reference: 1. NOURIANZ [package insert]. Kyowa Kirin, Inc., Bedminster, NJ, USA.

References: 1. Hickey P, Stacy M. Available and emerging treatments for Parkinson’s disease: a review. Drug Des Devel Ther. 2011;5:241-254. 2. The voice of the patient: Parkinson’s disease. Silver Spring, MD: US Food and Drug Administration; April 2016. https://www.fda.gov/media/124392/download. Accessed June 11, 2019. 3. Parkinson’s Foundation. Statistics. https://parkinson.org/Understanding-Parkinsons/Statistics. Accessed May 5, 2019. 4. Stocchi F, Antonini A, Barone P, et al. Early DEtection of wEaring off in Parkinson disease: the DEEP study. Parkinsonism Relat Disord. 2014;20(2):204-211. 5. NOURIANZ [package insert]. Kyowa Kirin, Inc., Bedminster, NJ, USA.

References: 1. Data on file. 2. NOURIANZ [package insert]. Kyowa Kirin, Inc., Bedminster, NJ, USA.

Reference: 1. NOURIANZ [package insert]. Kyowa Kirin, Inc., Bedminster, NJ, USA.