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Learn About Peter and Kelly’s Journey

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Peter: My name’s Peter. This is my wife, Kelly. We have two sons in college and a little dog, Lily, and a little cat named Coco.

Kelly: And this was a big year for us because we celebrated our 30th wedding anniversary.

Peter: It’s 30 already?

Kelly: He’s a very funny guy.

Peter: Well, I was first diagnosed in January of 2014. But what happened was I thought I had a pinched nerve in my neck, because my hand seemed a little wonky. So I went to see my general practitioner and she told me that I should go see a neurologist.

Peter: So I went and saw my neurologist and it turned out that I had Parkinson's.

Peter: It didn't seem real. It seemed like it couldn't be because I felt good. I'd always exercised and I was still exercising.

Kelly: When Peter came home and told me about the diagnosis, we were matter-of-fact about it. We really said, "Okay. Well, what do we do?"

Kelly: The neurologist was very reassuring. Her demeanor and her level of expertise presented it in a very matter-of-fact way so that I don't think it was as devastating to us.

Peter: The treatment that my doctor suggested that we started with was Levodopa-Carbidopa, which worked fairly well for quite a while.

Peter: I had no idea about “off” times ‘til I went to some meetings online with some of the organizations that my doctor suggested I get involved with and talk to the people there, and they were having a presentation about “off” times, and I suddenly realized that I was having the “off” times.

Kelly: I think that we knew things were happening. We just hadn't identified them.

Peter: I know what it was. When I was having an "off" episode, it would kind of...the whole thing. That’d go do the whole arm, would start moving. It’s embarrassing, frankly. So it’s something where you would be sitting somewhere and you’d stick it behind your back, which didn’t do much. But if it’s moving and shaking, it’s uhm…

Kelly: It’s noticeable.

Peter: It’s noticeable.

Peter: It was kind of upsetting because you thought you were doing everything that you could do and it wasn't working the way it had been. And you were having a situation where you were having an "off" time and your body was doing something that you didn't want it to do. Your tremors were getting more pronounced.

Peter: So I spoke to my doctor about it, my neurologist about it.
What the doctor said to me was that she wanted me to continue with the medications that I was already taking. But to add NOURIANZ.

Peter: What my doctor told me to do was to start it with 20 milligrams. We ended up upping it to 40 milligrams. I take it first thing in the morning, which is very convenient. It works for me, it works for my schedule.

Kelly: Made it easier for us to plan things as well.

Peter: My personal experience is that I have not had any or experienced any side effects from taking NOURIANZ. That might not be typical of every person who uses it.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Individual patient results may vary. Keep watching for more important safety information about NOURIANZ.

Peter: What I would tell caregivers is to take it one step at a time, because you're going to have hard times. But if you address the problem in front of you as best as you possibly can, and then the next problem you address as best as you possibly can, you’ll just keep finding solutions, the best possible solution.

Kelly: It would be so easy to become overwhelmed when you think about the long run. So it's easier to focus on what you have in front of you and just attack it gradually.

Peter: If you have Parkinson's and you find you're having "off" time, I would strongly suggest you talk to your doctor.

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes. It is not known if NOURIANZ is safe and effective in children.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of abnormal movement (dyskinesia)
  • have reduced liver function
  • smoke cigarettes
  • are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

  • uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
  • hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
    • being overly suspicious or feeling people want to harm you (paranoid ideation)
    • believing things that are not real (delusions)
    • seeing or hearing things that are not real (hallucinations)
    • confusion
    • increased activity or talking (mania)
    • disorientation
    • aggressive behavior
    • agitation
    • delirium (decreased awareness of things around you)
  • unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Talk to your doctor to find out if adding NOURIANZ is right for you. To learn more, visit NOURIANZ.com

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How NOURIANZ Works

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Transcript

This video is provided for educational purposes only and is not intended to replace discussions with your healthcare provider.

The product information provided in this video is intended only for residents of the US.

In your brain, there are chemicals that occur naturally to help control movement.

One chemical is dopamine. Dopamine works like pressing the gas pedal in a car to help your body move.

Adenosine is a different brain chemical that works like pressing the brake pedal to limit movement.

Normally, adenosine and dopamine work together in balance to help you move the way you want to.

However, in Parkinson’s disease, there is too little dopamine activity and too much adenosine activity. It’s like letting off the gas pedal while pressing on the brake pedal.

This imbalance can cause Parkinson’s symptoms such as difficulty in moving.

Many treatments for Parkinson’s disease, including levodopa/carbidopa, focus on increasing dopamine activity.

But over time, levodopa/carbidopa can start to wear off and stop working well and Parkinson's disease symptoms can return. When this happens, people may experience “off” time.

NOURIANZ® (istradefylline) is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease who are having “off” episodes. It is not known if NOURIANZ is safe and effective in children. It works differently from other add-on medicines for “off”-time.

NOURIANZ is the first and only treatment that lifts the brake of adenosine for “off” time in Parkinson’s disease. Although it is unknown how exactly NOURIANZ works, it is believed that decreasing adenosine activity is like lifting the brake in a car. This helps to increase movement for people experiencing “off” time.

If you are currently taking levodopa/carbidopa and are experiencing “off” time, it may be time to talk to your doctor about lifting the brake of adenosine by adding NOURIANZ.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of abnormal movement (dyskinesia)
  • have a history of psychotic thinking or behavior
  • have reduced liver function
  • smoke cigarettes or use other tobacco products
  • are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?

NOURIANZ may cause serious side effects, including:

  • uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
  • hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
    • being overly suspicious or feeling people want to harm you (paranoid ideation)
    • believing things that are not real (delusions)
    • seeing or hearing things that are not real (hallucinations)
    • confusion
    • increased activity or talking (mania)
    • disorientation
    • aggressive behavior
    • agitation
    • delirium (decreased awareness of things around you)
  • unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information for NOURIANZ.

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Downloadable Materials

Download the NOURIANZ® (istradefylline) brochure for adults living with Parkinson’s disease

NOURIANZ Brochure

A helpful guide for patients considering NOURIANZ, explaining what it is
and how it works.

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DOCTOR DISCUSSION GUIDE

Doctor Discussion Guide

A tool to help you recognize the impact of the “off” time you may be
experiencing with Parkinson’s disease (PD), and how to talk to your
doctor about it.

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Frequently Asked Questions

  • What is an “off” episode, or “off” time?

    • An “off” episode is a time when a patient’s PD symptoms, such as tremors and difficulty walking, return in between medication doses.

  • Can NOURIANZ® reduce “off” time?
  • What are the possible side effects of NOURIANZ?

    • NOURIANZ may cause serious side effects,
      including:

      • uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects. NOURIANZ may cause uncontrolled sudden movements or make such movements you already have worse or more
        frequent. Tell your healthcare provider if this happens.
      • hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
        • being overly suspicious or feeling people want to harm you (paranoid ideation)
        • believing things that are not real (delusions)
        • seeing or hearing things that are not real (hallucinations)
        • confusion
        • increased activity or talking (mania)
        • disorientation
        • aggressive behavior
        • agitation
        • delirium (decreased awareness of things around you)

      If you have hallucinations or any other abnormal thinking or behavior, talk with your healthcare provider.

      • unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

      If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

      The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

      These are not all the possible side effects of NOURIANZ.

      Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

  • What should my healthcare provider know before deciding if NOURIANZ may be right for me?

    • Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

      • have a history of abnormal movement (dyskinesia)
      • have reduced liver function
      • smoke cigarettes or use other tobacco products
      • are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
      • are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed

      Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

      NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

      Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

  • How should NOURIANZ be taken?
      • Take NOURIANZ exactly as your healthcare provider tells you to
      • Take NOURIANZ one time each day
      • You can take NOURIANZ with or without food
      • If you take too much NOURIANZ, call your healthcare provider or go to the nearest hospital emergency room right away
  • What are the ingredients in NOURIANZ?

    • The active ingredient in NOURIANZ is istradefylline. The inactive ingredients are crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, hypromellose, polyethylene glycol 3350, titanium dioxide, triacetin, iron oxide red, iron oxide yellow, and carnauba wax.

  • Is there financial support for out-of-pocket treatment costs for NOURIANZ?

    • If your doctor has prescribed NOURIANZ and you need help with the out-of-pocket cost, the Kyowa Kirin Cares program may be able to help.

      Eligible commercially insured patients may pay as little as $20 for a 1-month supply of NOURIANZ. For full program eligibility requirements, terms, conditions, and limitations, click here.

      Kyowa Kirin Cares also provides information, support, and other resources to eligible patients. For more information about Kyowa Kirin Cares, click here.

      If you need help paying for NOURIANZ, the Kyowa Kirin Cares program may be able to help you get the information and resources you need to start and stay with NOURIANZ.

      Visit Kyowa Kirin Cares for more information, including full eligibility requirements, terms, and conditions.

Organizations for patients with Parkinson’s disease (PD)
and their care partners

*Kyowa Kirin proudly sponsors the organization’s initiatives and goals through funding support.

The Michael J. Fox Foundation

www.michaeljfox.org

Dedicated to finding a cure and ensuring the development of improved therapies

Parkinson’s Foundation*

www.parkinson.org

To make life better through improved care and advance research for a cure

American Parkinson Disease Association

www.apdaparkinson.org

Provides information, education, support, activities, events, and referrals

Davis Phinney Foundation For Parkinson’s*

www.davisphinneyfoundation.org

Funds essential information, tools, inspiration for those living with PD, as well as research on exercise, speech, movement, and more

Parkinson & Movement Disorder Alliance

www.pmdalliance.org

Provides opportunities for meaningful connections through national, independent non-profit funding

Getting NOURIANZ Care Partners Support
arrow

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes. It is not known if NOURIANZ is safe and effective in children.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of abnormal movement (dyskinesia)
  • have reduced liver function
  • smoke cigarettes
  • are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

  • uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
  • hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
    • being overly suspicious or feeling people want to harm you (paranoid ideation)
    • believing things that are not real (delusions)
    • seeing or hearing things that are not real (hallucinations)
    • confusion
    • increased activity or talking (mania)
    • disorientation
    • aggressive behavior
    • agitation
    • delirium (decreased awareness of things around you)
  • unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information for NOURIANZ.